Respiratory viral infections during the first 28 days after transplantation in pediatric hematopoietic stem cell transplant recipients
Identifieur interne : 000C16 ( Main/Exploration ); précédent : 000C15; suivant : 000C17Respiratory viral infections during the first 28 days after transplantation in pediatric hematopoietic stem cell transplant recipients
Auteurs : JI HYUN LEE [Corée du Sud] ; Ja-Hyun Jang [Corée du Sud] ; SOO HYUN LEE [Corée du Sud] ; Yae-Jean Kim [Corée du Sud] ; KEON HEE YOO [Corée du Sud] ; Ki-Woong Sung [Corée du Sud] ; NAM YONG LEE [Corée du Sud] ; Chang-Seok Ki [Corée du Sud] ; HONG HEO KOO [Corée du Sud]Source :
- Clinical transplantation [ 0902-0063 ] ; 2012.
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Abstract
Respiratory viruses (RVs) are a known cause of morbidity and mortality after hematopoietic stem cell transplantation (HSCT). In this retrospective study, we focused on the first 28 d after transplantation in pediatric HSCT recipients and showed that a multiplex PCR assay significantly increased RV detection compared with a viral culture method. Among 176 pediatric HSCT recipients, 84 with respiratory symptoms within one yr after HSCT were tested by viral culture or multiplex PCR. Within 28 d after HSCT, nine patients were infected with RVs; the incidence of a first episode of RV infection within 28 d after HSCT was 5.1 %. Eight patients recovered without complications. However, one patient died of adenovirus (AdV) pneumonia with pulmonary hemorrhage; the mortality rate of RV infection within 28 d after HSCT was 0.57%. In the nine patients with RV infection, five different types of RV were identified, either alone or with another RV. These were corona virus (CoV), rhinovirus (RhV) and respiratory syncytial virus combined with CoV; AdV combined with RhV; and parainfluenza virus. Viral culture detected only one case of RV infection, while multiplex PCR detected eight, suggesting that screening of respiratory infections using multiplex PCR is better than the conventional culture method.
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Hyun" uniqKey="Jang J" first="Ja-Hyun" last="Jang">Ja-Hyun Jang</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Laboratory Medicine and Genetics, Samsung Medical Center, Sungkyunkwan University School of Medicine</s1><s3>KOR</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ></inist:fA14><country>Corée du Sud</country><wicri:noRegion>Department of Laboratory Medicine and Genetics, Samsung Medical Center, Sungkyunkwan University School of Medicine</wicri:noRegion></affiliation></author><author><name sortKey="Soo Hyun Lee" sort="Soo Hyun Lee" uniqKey="Soo Hyun Lee" last="Soo Hyun Lee">SOO HYUN LEE</name><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine</s1><s2>Seoul</s2><s3>KOR</s3><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>9 aut.</sZ></inist:fA14><country>Corée du Sud</country><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation></author><author><name sortKey="Kim, Yae Jean" sort="Kim, Yae Jean" uniqKey="Kim Y" first="Yae-Jean" last="Kim">Yae-Jean Kim</name><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine</s1><s2>Seoul</s2><s3>KOR</s3><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>9 aut.</sZ></inist:fA14><country>Corée du Sud</country><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation></author><author><name sortKey="Keon Hee Yoo" sort="Keon Hee Yoo" uniqKey="Keon Hee Yoo" last="Keon Hee Yoo">KEON HEE YOO</name><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine</s1><s2>Seoul</s2><s3>KOR</s3><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>9 aut.</sZ></inist:fA14><country>Corée du Sud</country><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation></author><author><name sortKey="Sung, Ki Woong" sort="Sung, Ki Woong" uniqKey="Sung K" first="Ki-Woong" last="Sung">Ki-Woong Sung</name><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine</s1><s2>Seoul</s2><s3>KOR</s3><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>9 aut.</sZ></inist:fA14><country>Corée du Sud</country><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation></author><author><name sortKey="Nam Yong Lee" sort="Nam Yong Lee" uniqKey="Nam Yong Lee" last="Nam Yong Lee">NAM YONG LEE</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Laboratory Medicine and Genetics, Samsung Medical Center, Sungkyunkwan University School of Medicine</s1><s3>KOR</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ></inist:fA14><country>Corée du Sud</country><wicri:noRegion>Department of Laboratory Medicine and Genetics, Samsung Medical Center, Sungkyunkwan University School of Medicine</wicri:noRegion></affiliation></author><author><name sortKey="Ki, Chang Seok" sort="Ki, Chang Seok" uniqKey="Ki C" first="Chang-Seok" last="Ki">Chang-Seok Ki</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Laboratory Medicine and Genetics, Samsung Medical Center, Sungkyunkwan University School of Medicine</s1><s3>KOR</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ></inist:fA14><country>Corée du Sud</country><wicri:noRegion>Department of Laboratory Medicine and Genetics, Samsung Medical Center, Sungkyunkwan University School of Medicine</wicri:noRegion></affiliation></author><author><name sortKey="Hong Heo Koo" sort="Hong Heo Koo" uniqKey="Hong Heo Koo" last="Hong Heo Koo">HONG HEO KOO</name><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine</s1><s2>Seoul</s2><s3>KOR</s3><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>9 aut.</sZ></inist:fA14><country>Corée du Sud</country><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation></author></analytic><series><title level="j" type="main">Clinical transplantation</title><title level="j" type="abbreviated">Clin. transplant.</title><idno type="ISSN">0902-0063</idno><imprint><date when="2012">2012</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Clinical transplantation</title><title level="j" type="abbreviated">Clin. transplant.</title><idno type="ISSN">0902-0063</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Child</term><term>Hematopoietic stem cell transplantation</term><term>Homotransplantation</term><term>Korea</term><term>Medicine</term><term>Multiplex polymerase chain reaction</term><term>Pediatrics</term><term>Recipient</term><term>Respiratory system infection</term><term>Transplantation</term><term>Treatment</term><term>Viral disease</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Infection appareil respiratoire</term><term>Virose</term><term>Traitement</term><term>Homotransplantation</term><term>Transplantation</term><term>Enfant</term><term>Réaction chaîne polymérase multiplex</term><term>Pédiatrie</term><term>Receveur</term><term>Corée</term><term>Médecine</term><term>Greffe de cellules souches hématopoïétiques</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Enfant</term><term>Pédiatrie</term><term>Médecine</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Respiratory viruses (RVs) are a known cause of morbidity and mortality after hematopoietic stem cell transplantation (HSCT). In this retrospective study, we focused on the first 28 d after transplantation in pediatric HSCT recipients and showed that a multiplex PCR assay significantly increased RV detection compared with a viral culture method. Among 176 pediatric HSCT recipients, 84 with respiratory symptoms within one yr after HSCT were tested by viral culture or multiplex PCR. Within 28 d after HSCT, nine patients were infected with RVs; the incidence of a first episode of RV infection within 28 d after HSCT was 5.1 %. Eight patients recovered without complications. However, one patient died of adenovirus (AdV) pneumonia with pulmonary hemorrhage; the mortality rate of RV infection within 28 d after HSCT was 0.57%. In the nine patients with RV infection, five different types of RV were identified, either alone or with another RV. These were corona virus (CoV), rhinovirus (RhV) and respiratory syncytial virus combined with CoV; AdV combined with RhV; and parainfluenza virus. Viral culture detected only one case of RV infection, while multiplex PCR detected eight, suggesting that screening of respiratory infections using multiplex PCR is better than the conventional culture method.</div></front></TEI><affiliations><list><country><li>Corée du Sud</li></country><region><li>Région capitale de Séoul</li></region><settlement><li>Séoul</li></settlement></list><tree><country name="Corée du Sud"><noRegion><name sortKey="Ji Hyun Lee" sort="Ji Hyun Lee" uniqKey="Ji Hyun Lee" last="Ji Hyun Lee">JI HYUN LEE</name></noRegion><name sortKey="Hong Heo Koo" sort="Hong Heo Koo" uniqKey="Hong Heo Koo" last="Hong Heo Koo">HONG HEO KOO</name><name sortKey="Jang, Ja Hyun" sort="Jang, Ja Hyun" uniqKey="Jang J" first="Ja-Hyun" last="Jang">Ja-Hyun Jang</name><name sortKey="Keon Hee Yoo" sort="Keon Hee Yoo" uniqKey="Keon Hee Yoo" last="Keon Hee Yoo">KEON HEE YOO</name><name sortKey="Ki, Chang Seok" sort="Ki, Chang Seok" uniqKey="Ki C" first="Chang-Seok" last="Ki">Chang-Seok Ki</name><name sortKey="Kim, Yae Jean" sort="Kim, Yae Jean" uniqKey="Kim Y" first="Yae-Jean" last="Kim">Yae-Jean Kim</name><name sortKey="Nam Yong Lee" sort="Nam Yong Lee" uniqKey="Nam Yong Lee" last="Nam Yong Lee">NAM YONG LEE</name><name sortKey="Soo Hyun Lee" sort="Soo Hyun Lee" uniqKey="Soo Hyun Lee" last="Soo Hyun Lee">SOO HYUN LEE</name><name sortKey="Sung, Ki Woong" sort="Sung, Ki Woong" uniqKey="Sung K" first="Ki-Woong" last="Sung">Ki-Woong Sung</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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